Malignant Giant Cell Tumor

Introduction

This bone tumor is rare. It is much more common in females than males and occurs after bone growth is finished. It develops at the extreme end of long bones in proximity to or even being part of the joint. 75% of these cancers develop around the knee joint, the sacrum or the vertebrae. With every recurrence after treatment the new tumor tissue becomes more resistant and difficult to treat.

Initially there is low potential for distant metastases, after the first recurrence there is a 30 to 40% malignant transformation with the potential for distant metastases.

Symptoms

The first symptom is usually joint pain in a mass that is developing in or near a joint. There is joint effusion, a mass at the bone and the range of motion in the affected joint is decreased.

Tests

X-rays suggest the diagnosis to an extent, but this alone is not reliable. A bone biopsy where the typical giant cells are found together with other histological characteristics will make the diagnosis.

Treatment

Surgery with a complete removal is the treatment of choice. It will cure 90% of this type of bone cancer. Because recurrence with this tumor is high, if not all cancer is removed, the orthopedic surgeon will want to make certain that all of the cancerous tissue is completely removed.

This is done by complete resection, if this is feasible or else by careful curettage and cryosurgery with a probe with liquid nitrogen. This technique of combined curettage and cryosurgery allows the surgeon to eradicate the tumor while preserving joint motion and avoiding amputation or resection. In capable hands as few as only 2% recurrences occur after the first surgery, a 10-fold decrease from the old technique, which was associated with 20 % or more recurrences. Other successful techniques are radiotherapy in a major Cancer Clinic with experience in this rare bone tumor. There were some fears of late malignant complications following radiotherapy in the past, but it turned out that the reoccurrences were due to inadequate dosage of the radiation treatment. Chemotherapy does not work with this type of bone cancer.

Pain relief:

There is an FDA approved non-drug method available, IceWave patches from Lifewave, which will control pain. This is mentioned in the book "Breakthrough" by Suzanne Somers (Ref. 5) where newer insights of antiaging medicine are also reviewed. Although the patches are placed over acupuncture points, there are no needles involved. Nanotechnology, a newer technology, was used in the manufacturing of these patches and infrared (heat) waves from body heat are utilized to stimulate an acupuncture point, which modifies pain perception and reduces pain to half or less. Medically this would be considered an excellent pain reliever. For more info on the patches see the IceWave patches from Lifewave link above (click "products"). In the US a 5 pack of the IceWave spray is available that can be directly sprayed onto the skin in the area where the pain is located.

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Disclaimer

This outline is only a teaching aid to patients and should stimulate you to ask the right questions when seeing your doctor. However, the responsibility of treatment stays in the hands of your doctor and you.

References

1. Cancer: Principles &Practice of Oncology. 4th edition. Edited by Vincent T. DeVita, Jr. et al. Lippincott, Philadelphia,PA, 1993. Chapter on Sarcomas of the soft tissues and bone.

2. Cancer: Principles&Practice of Oncology. 5th edition, volume 2. Edited by Vincent T. DeVita, Jr. et al. Lippincott-Raven Publ., Philadelphia,PA, 1997. Chapter on Sarcomas of the soft tissues and bone.

3. Conn's Current Therapy 2004, 56th ed., Copyright © 2004 Elsevier

4. Ferri: Ferri's Clinical Advisor: Instant Diagnosis and Treatment, 2004 ed., Copyright © 2004 Mosby, Inc

5. Suzanne Somers: "Breakthrough" Eight Steps to Wellness-- Life-altering Secrets from Today's Cutting-edge Doctors", Crown Publishers, 2008

Last Modified: June 20, 2009