Stroke And Brain Aneurysm

Stroke and brain aneurysm (Choose a topic)
Brain aneurysm and subarachnoid hemorrhage
Hemorrhagic stroke
Other causes of strokes
Stroke (Ischemic stroke)
Stroke prevention
Transient ischemic attacks(TIA)


Introduction:

A stroke is a medical emergency where a person suddenly changes from functioning normally to a person who may have a set of complaints such as headaches, inability to move a body part and change in level of consciousness (dizziness, confusion, all the way to possible unconsciousness or coma).

In a dense stroke there may be an inability to move the muscles of one body half. Often the person may fall and if older, may break the more brittle bones (typically a hip fracture or wrist fracture) as the person is off balance and falls.The obvious thing to do for an onlooker is to call 9-1-1 to get an ambulance so that the patient can be transported to the nearest hospital. There the physician will stabilize the patient and arrange an emergency CT or MRI scan. Here is a simple test based on three brain functions that anyone can do, if you suspect a person around you may suffer from a stroke:

Stroke and brain aneurysm (recognize the symptoms)
*Ask the individual to SMILE.
*Ask him or her to RAISE BOTH ARMS.
*Ask the person to SPEAK A SIMPLE SENTENCE.

If he or she has trouble with any of these tasks, call 9-1-1 immediately and describe the symptoms to the dispatcher.

After discovering that a group of non-medical volunteers could identify facial weakness, arm weakness and speech problems, researchers urged the general public to learn the three questions. They presented their conclusions at the American Stroke Association's Annual meeting in February of 2004. Widespread use of this test could result in prompt diagnosis and treatment of a stroke and prevent brain damage.


In the following I am describing that there can be very different reasons for similar symptoms. For instance, the underlying pathology in the above example could be a brain tumor that presses onto the part of the brain that controls body motion. However, there might be a closing off of the middle cerebral artery on one side through a blood clot dislodged from heart valve disease (embolic stroke) or the middle cerebral artery may have been narrowed down so badly that one day it suddenly closes off completely (ischemic stroke).

This would be an example of an ischemic stroke on the basis of arteriosclerosis (hardening of the arteries), which happens for instance prematurely in a patient with diabetes mellitus, but which commonly happens also in old age. Another mechanism for stroke is with poorly controlled high blood pressure, when one of the small blood vessels may rupture and bleeding occurs in the brain tissue with identical symptoms as above (hemorrhagic stroke). Finally, in more rare cases a congenital pouch exists in one of the arteries of the brain, called brain aneurysm, which tends to rupture as the person ages and suddenly leads to a subarachnoid bleed (or hemorrhage).

In the following I shall deal with the most common conditions just mentioned (Ref. 9, p. 1538).

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Other Causes of Strokes

A primary brain tumor (benign of malignant) or a brain metastasis of a cancer elsewhere in the body (for instance lung cancer, melanoma, breast cancer or prostate cancer) can also produce the signs of a stroke. Clinically the first signs are often like an ischemic stroke. However, the CT scan or MRI scan would show the typical findings of a metastasis rather than an ischemic stroke. Also, in time this metastasis would increase in size while the ischemic stroke heals with a scar.

On the other hand a clot from a diseased heart valve (for instance from prior rheumatic heart valve disease) or a clot from an arteriosclerotic plaque at the bifurcation of the carotid artery will produce the clinical picture of an ischemic stroke. Sometimes such underlying diseases lead to a serious of mini strokes. Treatment with ASA or full anticoagulation initially with heparin and later with Coumadin to thin the blood might have to be done. If other medical illnesses such as diabetes mellitus or hypertension are present, these conditions would have to be treated diligently and persistently. It is important that the patient understands that a one-time treatment of these conditions will not change the long-term risk. However, I want the patient to understand also, that long-term control of hypertension and diabetes mellitus will produce marvelous results. I know how difficult it is to be persistent. But this is an area where the affected person becomes his or her own hero and the gold medal in this Olympic event is the prolongation of your life!

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Stroke Prevention

A chapter on strokes would not be complete, if nothing would be mentioned about stroke prevention. Physicians are very limited with what they can do when a stroke has happened as brain tissue has often been lost and scarring sets in following a stroke. Looking at tooth decay it is certainly important to think about the cause of plaque formation, tooth decay and eventual tooth loss. After identifying the risk factors the next step is to cut out sugar consumption, brush your teeth and floss them regularly. Many of you know that and those of you who do this regularly likely still have their own teeth.

What does that have to do with prevention of strokes? The same preventative thinking works in stroke prevention. I have mentioned earlier and in other parts of the Net Health Book that there are preventable risk factors that lead to stroke. For ease of reference I have listed them in tabular form here again (modified from Ref.12).

Risk factors important for stroke prevention
Risk factors:Comments:
Diabetes premature hardening of arteries, best prevented by close diabetic control
Dietary factors low fat, low refined carbohydrate diet, which is good for your teeth is also good for your body
Inactivitythe blood needs to circulate and HDL-cholesterol needs to be built up be regular exercise (45 to 55 minutes of a brisk walk every day)
Hypertensiondon't get it and if you have it use medicine and life style changes to keep it under close control
Hyperlipemiahigh blood fats in your blood cannot be good for your heart or brain arteries. If you have this, see your doctor and get medicine to control it closely.
Obesitythis did not happen overnight. You tackle this by attacking inactivity, dietary factors and mental attitute all at the same time. It can be done. Get support, cut out the main offenders to get started.
Smokingthis is an addiction to nicotine. It may go much deeper than you think. Smoking can be an escape from stresses in life. Whichever way works for you, you need to get off cigarettes and other addicting stuff.

Dr. Philip A. Teal from the Vancouver General Hospital (Director of the British Columbia Centre for Stroke and Cerebrovascular Disease) gave a talk at this conference (Ref.12) entitled "Stroke Prevention."

He stated that about 80% of strokes are preventable through life style changes by paying attention to what I summarized for you in the table above. He also said that they found in BC that about 40 % of all strokes originated from diabetes, hyperlipidemia and high blood pressure that were not adequately controlled and from smoking that had not been stopped. In other words these were entirely preventable. The other 40% of preventable causes are lifestyle decisions regarding food intake and inactivity. These BC vital statistics are identical in the US and in many other parts of the world. Many people have enough will power to change this on their own. Others need to do it under the guidance of a YMCA program or other equivalent program. Like brushing your teeth, limiting your sugar intake and flossing your teeth, which are very simple steps to take, you need to pay attention to your body, particularly the arteries that go to the brain and heart. Whatever I suggested in the table above is good not only for your brain, but also for your heart. It's a "two-for-one-deal".

In those patients where a transient ischemic attack has taken place urgent tests of the carotid arteries are needed, as a high percentage may have severe narrowing of the arteries predisposing them to the development of a stroke in the near future. Carotid endarterectomy can be done for this with a success rate of stroke prevention in 70 to 80 % of patients (with proper selection of the patients who will benefit).

Those who had a stroke can do "secondary prevention" by taking a baby aspirin daily to thin the blood and this can be combined with extended release clopidrogel or dipyridamole. Ask you family doctor or specialist about this. Risks and benefits of medications have to be assessed in each patient according to the circumstances. As you know aspirin (ASA) can cause severe stomach bleeding in a small number of patients.

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Disclaimer:

This outline is only a teaching aid to patients and should stimulate you to ask the right questions when seeing your doctor. However, the responsibility of treatment stays in the hands of your doctor and you.

References:

1. KH Lee et al. Arch Neurol 2000 Jul 57(7): 1000-1008.

2. S Schmulling et al. Stroke 2000 Jul 31(7): 1552-1554.

3. D Jackson et al. Clin Rehabil 2000 Oct 14(5): 538-547.

4. ML Hackett et al. Neurology 2000 Sep 12; 55 (5): 658-662.

5. K Tsutsumi et al. J Neurosurg 2000 Oct 93( 4): 550-553.

6. IS Spetzler Surg Neurol 2000 Jun 53(6): 530-540.

7. G Lot et al. Acta Neurochir (Wien) 1999; 141(6): 557-562.

8. The Merck Manual, 7th edition, by M. H. Beers et al., Whitehouse Station, N.J., 1999. Chapter 174.

9. Noble: Textbook of Primary Care Medicine, 3rd ed.,2001, Mosby Inc.

10. Ferri: Ferri's Clinical Advisor: Instant Diagnosis and Treatment, 2004 ed., Copyright © 2004 Mosby, Inc.

11. Rakel: Conn's Current Therapy 2004, 56th ed., Copyright © 2004 Elsevier

Last Modified: Dec. 23, 2008